Lung cancer development can be due to generic or environmental risk factors. Tobacco smoking is the leading environmental risk factor that contributes to lung cancer. Yafang Li led Dartmouth research team to conduct a study to prove that a gene-smoking interaction leads to lung cancer.
In their research, three novel single-nucleotide polymorphisms (SNPs), or variations in DNA that underlie the exposure to develop the cancer were identified. The spotted novel SNPs provide biomarkers for lung cancer risk intervention and screening. Their findings are available in Carcinogenesis.
The team obtained phenotype and genotype data for the analysis from OncoArray Consortium. Many genome wide association types of research have limited interaction analysis power. This study is the most extensive genome-wide SNP reported for this kind of cancer. The researchers implemented a two-step approach in efforts to minimize power loss from normal gene-environment interaction review.
The SNPs identified in the study work confirmed that smoking behaviors leads could lead to lung cancer. Researchers use the three SNPs as biomarkers to categorize the risk of lung cancer to an individual. It focuses on smoking behaviors as the leading factor. Information obtained is helpful for treatment plan prediction and individualized prognosis.
The reported research was for the Caucasian population and could not be useful to other ethnicities due to different genetic origins. The group plans to further studies and test the effect of the identified interaction using samples from other inhabitants. Advancing their studies meant that they could determine other gene smoking interaction associated with lung cancer disease.
About Eric Lefkofsky
Eric Lefkofsky is currently the chief executive officer and co-founder of Tempus. Tempus is a technology entity and concentrates on battling cancer disease. Mr. Lefkofsky is a founding partner and chair of Groupon, a universal commerce marketplace. He is also the co-founder of Lightbank, Uptake Technologies, Mediaocean, Echo Global Logistics, and InnerWorkings.
Eric Lefkofsky opened Lefkofsky Family Foundation in 2006 to improve the quality of life of the communities served. He gained support from his loved ones when running the charity organization. Eric Lefkofsky is the Trustee of The Art Institute of Chicago, Lurie Children’s Hospital of Chicago, and The Museum of Science and Industry and World Business Chicago.
The philanthropist oversees the activities of the Steppenwolf Theatre, Chicago Board of Trustees. He works at the University of Chicago as an adjunct professor and author. Eric Lefkofsky is a former student at University of Michigan Law School.
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